Raspberry Ketones

Dr. Oz video

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OK I can’t lie, this video is painful to actually listen to, but you can mute it and still watch it OK.

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From emaxhealth.com: http://www.emaxhealth.com/8782/raspberry-ketone-much-more-belly-fat-busting-supplement-says-study

http://www.emaxhealth.com/8782/what-evidence-supports-fat-burning-raspberry-ketone-claims

Interest in raspberry ketone supplements originate from a 1995 study published in the journal Life Sciences where Japanese researchers reported their findings that mice on a high fat diet supplemented with a raspberry ketone supplement were protected from obesity.

Raspberry ketones are aromatic compounds of the red raspberry that are commonly used as flavor and scent additives. What stimulated anti-obesity related research with raspberry ketones is due to their similarity to the capsaicin found in chili pepper plants, which is also believed to possess anti-obesity and lipid metabolizing properties.

The researchers of the study determined that raspberry ketones provided protection from obesity in mice by significantly increasing norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase from the cytosol to lipid droplets in white fat cells. In other words, raspberry ketones induce cells to burn stored fat.

On the Dr. Oz show, weight loss expert and dietician Lisa Lynn illustrates the benefits of raspberry ketones by showing before and after images of patients of hers that have lost significant amounts of weight that they attribute to adding raspberry ketone supplements to their diet and weight loss plans. However, even if the images are true, they are a far cry from rigorous research that can quantitatively support or discount the fat burning effects of raspberry ketones on the body.

The point to all of this is that the argument can be made that in some cases, knowing the exact scientific truth of whether a supplement does or does not burn fat may be irrelevant.

One of the primary tenets of medicine is to first do no harm. And as many doctors will attest, part of the art of medicine is knowing how to meet the needs of particular patients who may benefit from non-science backed guidance—as long as it causes no harm. According to the FDA (Food and Drug Administration) raspberry ketones qualify as a substance under GRAS (generally recognized as safe) status for human consumption. Furthermore, there are several studies that show value in health with the placebo effect—which may be the real reason in the before and after success stories.

Aside from a counter argument that dieters who buy these products in hopes of losing weight are being duped by the supplement industry, as long as the buyer is sufficiently mentally capable of understanding that the caveat buyer beware applies, then where’s the harm? Can we not see more redeeming character in someone who at least attempts to lose weight over someone who does not try?

It is just as easy to dismiss something as hokum as it is to believe that something is true—it’s human nature. And if there’s one thing we know about dieting and weight loss that is true is that what works for one person, may not work for another. Claims of the fat burning properties of burning raspberry ketones may not have sufficient supporting scientific evidence, but what they do have is the drive of people who want to improve their health.

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Now an article from Labrada (sports nutrition company):

http://www.labrada.com/raspberryketones#deepIntro

Raspberry Ketones – The Easy, Natural Solution for Anyone Who’s Struggled to Lose Fat

Every woman who has struggled to lose weight knows the secrets to disguising extra fat. Wear all black to look slimmer. Avoid bold patterns on problem areas. Steer clear of horizontal stripes. Suck those extra inches in with “thinning” undergarments (even if you can’t breathe). And if all else fails – go baggy to hide everything!

All of this careful disguise work can be … well … exhausting!

The problem isn’t limited to women, either. Guys who battle pot bellies, love handles, and other stubborn trouble spots have mastered the art of disguise too. You’ll commonly see these body-conscious men wearing oversized clothes on a hot summer’s day or T-shirts in the pool, just to hide their “single pack.”

But take heart, because if you can relate to any of these scenarios, your days of camouflaging the fat are over. Thanks to new Raspberry Ketones, it’s time to lose the fat – once and for all!

What are raspberry ketones – and why all the buzz about them?

Benefits:

  • Stimulates Fat Loss
  • Inhibits Fat Absorption
  • Increases Fat Burning (Fat Oxidation)
  • 30 Day Supply – 60 Capsules

Raspberry ketones are the natural compounds found in raspberries, responsible for their distinct aroma. Research suggests that these powerful compounds can actually stimulate fat loss and regulate metabolism through a number of different pathways, especially when paired with regular diet and exercise (For a more detailed account of these pathways, click here). Understanding the power and effectiveness of raspberry ketones, Labrada has introduced its new, all-natural Raspberry Ketones supplement. If it seems like everywhere you go more and more people are talking about this product, we’re not surprised. Everyday people using Raspberry Ketones are seeing real results – and now it’s time to get in on the action! No matter what your age or where you struggle most with extra fat, you’ll notice the difference with Raspberry Ketones soon after taking it.

When the real thing isn’t best

You might be thinking, “So why not just eat some whole raspberries?” Not a bad idea – that is, if you could stomach the sheer volume of raspberries needed to get the same amount of ketones found in Raspberry Ketones. To experience comparable weight-loss benefits, experts estimate that you would need to consume a whopping 90 pounds of raspberries! Clearly, this is not realistic – neither physically nor financially! With Raspberry Ketones, you can skip the bushels of raspberries and get the ingredients you need in a condensed, more manageable serving size – in two easy capsules, to be exact!

Not a magic pill … but close to it

There is just no denying the power and overall health benefits of regular exercise and healthy eating. At Labrada, we’ve never been about a quick fix. But a quick support system? Who wouldn’t want that? Raspberry Ketones gives you that extra push you need to get past mediocre results and into the territory where friends and family are suddenly asking you how you’ve gotten so lean. Just think of Raspberry Ketones as your complement – not replacement – to balanced, healthy living. You’ve done the hard work by getting active and cleaning up your diet; now Raspberry Ketones will give you a helping hand to maximize your results. No more “wardrobe deception” needed!

Want to Dig Deeper Into The Science?

Third-party, unbiased research on raspberry ketones shows how powerful these compounds are at helping to shrink fat cells and prevent your body from storing extra body fat. To learn more about the mechanisms behind raspberry ketones, we invite you to read the data below by Monica Mollica, nutritional research scientist from the University of Stockholm.

What are Raspberry Ketones?

Raspberry ketones are phenolic compounds (a class of natural substances found in plants) derived from red raspberries. Raspberry ketones are responsible for the distinct aroma of raspberries, and are commonly used as a fragrance and/or food flavoring. When taken as a dietary supplement, raspberry ketones, Dr. Oz suggests, has been shown to increase fat loss through a number of different pathways.

Raspberry has been used throughout the centuries for nutritional and medicinal purposes. Like its popular relatives, the strawberry and blueberry, raspberry contains an abundance of health promoting substances. The unique fragrance and flavor of raspberry comes from raspberry ketone (also known as 4-(4-hydroxyphenyl) butan-2-one) 1, which is unique to a raspberry, and is widely used as a fragrance in cosmetics and as a flavoring agent in foodstuffs 2.

Raspberry Ketones for Fat Loss

Studies have shown that raspberry ketones hold promise for fat loss. In one study mice were fed a calorie rich high-fat diet supplemented with raspberry ketones. After 10 weeks it was shown that the raspberry ketone supplementation prevented both subcutaneous and abdominal (visceral) fat gain, and also protected against development of fatty liver 3. These anti-obesity effects are beneficial, since abdominal fat (the type of fat that causes protruding bellies even in otherwise “skinny” people) is strongly associated with obesity-related complications like the metabolic syndrome, Type 2 diabetes and coronary artery disease, even in the absence of classical risk factors 4,5. The association between abdominal adiposity and accelerated atherosclerosis has been shown to be independent of age, overall obesity or the amount of subcutaneous fat 5. Thus, raspberry ketones can help you get in better shape and improve your health.

How Do They Work?

Raspberry ketones appear to stimulate fat loss several ways:

1. Increasing liberation of fat from fat stores (a process called lipolysis) 3,6.

2. Enhancing energy expenditure by activating thermogenesis (heat production) in brown adipose tissue (also known as BAT, see below) 3.

3. Increasing fat burning (fat oxidation) 3,6.

4. Increasing levels of the hormone adiponectin 6.

5. Suppress fat synthesis from fructose (sugar) overfeeding 3, and inhibit fat accumulation 6.

6. Inhibit fat absorption 3.

The effect of raspberry ketones on BAT and adiponectin are especially interesting.

BAT – Brown Adipose Tissue

Brown Adipose Tissue, also known as BAT, is a special type of fat tissue that produces heat instead of storing fat7. It was previously thought that BAT was only present in significant amounts in rodent, and infants 8. However, recently has been shown that even adult humans have metabolically active BAT depots9,10, that can be induced and stimulated7. This has put BAT in the spotlight of obesity research 8-11; thus, we are most likely going to hear a lot about BAT -in the near future. Bearing this in mind, it is interesting that raspberry ketones stimulate BAT induced increases in energy expenditure. The more you can increase your ability to burn off excess calories (by raising your energy expenditure), the better are your odds of shedding those unwanted pounds of fat.

Adiponectin – the fat cell hormone

Fat cells are often regarded as calorie storing depots. However, fat cells also secrete several substances hormones, both good and bad (depending on the location of the fat depots) 12-17. One of the good hormones secreted from fat cells is adiponectin 18-21. Adiponectin is a relatively newly discovered adipose tissue derived hormone that circulates in the blood at high levels 22, and has multiple health promoting effects.

Adiponectin enhances insulin sensitivity, lowers blood glucose (blood sugar) and reduces triglyceride levels22-24, in addition to boosting fat burning 25. Apart from its anti-diabetic, anti-hypertensive and anti-atherogenic properties, recent studies have revealed that adiponectin also has anti-inflammatory and anti-cancer functions 19-21,26,27. Actually, one mechanism by which abdominal fat causes metabolic and cardiovascular diseases is via a reduction in adiponectin levels 26. Low levels of adiponectin contribute to the development of insulin resistance, type 2 diabetes and cardiovascular diseases in obese or overweight people 18,22. Adiponectin levels are inversely related to the degree of adiposity 23, which means that the lower the adiponectin levels, the more fat we’re likely to be carrying around.

It is interesting that exercise, which is well known for all its beneficial health effects, also increases adiponectin levels 28. The importance of adiponectin is further underscored by proposals to make it a biomarker for different health conditions, and a therapeutic target for health promotion interventions 21. It has further been speculated that adiponectin – or interventions that stimulate adiponectin secretion or action – might play a role in the therapeutic armament against disease states associated with insulin resistance, mainly type 2 diabetes mellitus and obesity 29. Thus, the ability of raspberry ketones to increase adiponectin secretion undoubtedly contributes to the anti-obesity and health promoting effect.

Application and Serving Size

Raspberry ketones act via multiple pathways to stimulate fat loss and exert an anti-obesity effect. This distinguishes raspberry ketones from many other fat loss agents, which only act via a single mechanism. Another interesting aspect with raspberry ketones is that some of their mechanisms of action also have direct health promoting effects that reduce the risk for chronic illnesses such as cardiovascular disease, diabetes and the metabolic syndrome.

The supplement can be administered as a capsule, tablet, powder or liquid. The recommended serving is 100 mg twice daily.*

Dr. Oz’s Web site noted that raspberry ketone can be taken 30 minutes before a big meal to help weight loss.

As with any weight loss or weight management program, raspberry ketones should be used in conjunction with proper nutrition and exercise.

* The FDA has not evaluated these statement. This product is not intended to diagnose, treat, cure, or prevent any disease.

References:

  • 1Gallois A. Quantitative evaluation of raspberry ketone using thin-layer chromatography. . Sciences des Aliments. 1982;2(99–106).
  • 2Guichard E. Identification of the flavoured volatile components of the raspberry cultivar lloyd george. Sciences des Aliments. 1982;2(99–106).
  • 3Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H. Anti-obese action of raspberry ketone. Life sciences. May 27 2005;77(2):194-204.
  • 4Despres JP. Is visceral obesity the cause of the metabolic syndrome? Annals of medicine. 2006;38(1):52-63.
  • 5Hamdy O, Porramatikul S, Al-Ozairi E. Metabolic obesity: the paradox between visceral and subcutaneous fat.Current diabetes reviews. Nov 2006;2(4):367-373.
  • 6Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta medica. Oct 2010;76(15):1654-1658.
  • 7Fruhbeck G, Becerril S, Sainz N, Garrastachu P, Garcia-Velloso MJ. BAT: a new target for human obesity?Trends in pharmacological sciences. Aug 2009;30(8):387-396.
  • 8Cinti S. The role of brown adipose tissue in human obesity. Nutrition, metabolism, and cardiovascular diseases : NMCD. Dec 2006;16(8):569-574.
  • 9Nedergaard J, Cannon B. The changed metabolic world with human brown adipose tissue: therapeutic visions.Cell metabolism. Apr 7 2010;11(4):268-272.
  • 10Enerback S. Human brown adipose tissue. Cell metabolism. Apr 7 2010;11(4):248-252.
  • 11Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD, Reiter RJ. Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity. Obesity reviews : an official journal of the International Association for the Study of Obesity. Mar 2011;12(3):167-188.
  • 12Guerre-Millo M. Extending the glucose/fatty acid cycle: a glucose/adipose tissue cycle. Biochemical Society transactions. Dec 2003;31(Pt 6):1161-1164.
  • 13Guerre-Millo M. Adipose tissue and adipokines: for better or worse. Diabetes & metabolism. Feb 2004;30(1):13-19.
  • 14Deng Y, Scherer PE. Adipokines as novel biomarkers and regulators of the metabolic syndrome. Annals of the New York Academy of Sciences. Nov 2010;1212:E1-E19.
  • 15Rodriguez-Rodriguez E, Perea JM, Lopez-Sobaler AM, Ortega RM. [Obesity, insulin resistance and increase in adipokines levels: importance of the diet and physical activity]. Nutricion hospitalaria : organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral. Jul-Aug 2009;24(4):415-421.
  • 16Dyck DJ. Adipokines as regulators of muscle metabolism and insulin sensitivity. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. Jun 2009;34(3):396-402.
  • 17Catalan V, Gomez-Ambrosi J, Rodriguez A, Salvador J, Fruhbeck G. Adipokines in the treatment of diabetes mellitus and obesity. Expert opinion on pharmacotherapy. Feb 2009;10(2):239-254.
  • 18Guerre-Millo M. Adiponectin: an update. Diabetes & metabolism. Feb 2008;34(1):12-18.
  • 19Szmitko PE, Teoh H, Stewart DJ, Verma S. Adiponectin and cardiovascular disease: state of the art?American journal of physiology. Heart and circulatory physiology. Apr 2007;292(4):H1655-1663.
  • 20Ziemke F, Mantzoros CS. Adiponectin in insulin resistance: lessons from translational research. The American journal of clinical nutrition. Jan 2010;91(1):258S-261S.
  • 21Shetty S, Kusminski CM, Scherer PE. Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies. Trends in pharmacological sciences. May 2009;30(5):234-239.
  • 22Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. European journal of endocrinology / European Federation of Endocrine Societies. Mar 2003;148(3):293-300.
  • 23Nedvidkova J, Smitka K, Kopsky V, Hainer V. Adiponectin, an adipocyte-derived protein. Physiological research / Academia Scientiarum Bohemoslovaca. 2005;54(2):133-140.
  • 24Ravussin E. Adiponectin enhances insulin action by decreasing ectopic fat deposition. The pharmacogenomics journal. 2002;2(1):4-7.
  • 25Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH, Kim JB. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes. Sep 2006;55(9):2562-2570.
  • 26Matsuzawa Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2010;86(2):131-141.
  • 27Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clinica chimica acta; international journal of clinical chemistry. May 1 2007;380(1-2):24-30.
  • 28Simpson KA, Singh MA. Effects of exercise on adiponectin: a systematic review. Obesity (Silver Spring). Feb 2008;16(2):241-256.
  • 29Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature medicine. Aug 2001;7(8):941-946.

——————————————————————————————————————————————–<<< Personally I like the fact that Labrada actually posts the footnotes and resources they used for their piece.

Above are links I’ve found in a  search of Raspberry Ketones in youtube and on google.

So what’s all this hype about?

Alright, so we have the equivalent of any “magic bullet” type pill out there on the market.  Think about Sensa, Apidexin, Phenphedrine (phenphen), Alli (Xenical by prescription) and tons of others out there.  They aren’t all approved by the FDA (as a matter of fact, very FEW weight loss pills are.) Those that ARE FDA approved are all for “short term” loss, and even Xenical has not been tested on subjects for longer than  2 year period, so it could STILL have nasty side effects.

On the “other” hand we have a natural supplement (assuming you’d WANT to eat 90 pounds of raspberries)  that would promote fat cells to be released into the body for use (see the 3rd video, most helpful IMO).  The trick with people on diets already is that the Ketones were tested in rats with high fat intake, and Ideal Protein does not promote a high fat intake, as a matter of fact, fat is the second most restricted item on the diet (right behind carbohydrates).  Will I try it at some point?  Very possibly.  Will I try it before I hit some invisible wall (plateau) that I can’t seem to get around?  Nope.  Cost is actually around $25-$35/bottle, and the health benefits and consistency of the creation is awful, no two manufactures seem to have the same breakdown or even MG of the raspberry ketones.  Once more studies come out and if they prove that the raspberry ketones DO help the body release stored fat for burning, then I’d be more inclined to give this little red pill a shot.

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One comment on “Raspberry Ketones

  1. Pingback: Little Raspberry Riding Hood « Thinking Thin

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